• Roughly years have gone by since the identification of

  2019-06-28

  

  Roughly 15 years have gone by since the identification of the main characters involved in the interplay of the RANK–RANKL system. This gave rise to the race for elucidating their biological role . In those years, in vivo silencing experiments for both Receptor Activator of Nuclear Factor κ B (RANK)

• The pathophysiology underlying ONJ is unclear

  2019-06-28

  

  The pathophysiology underlying ONJ is unclear. Decreased bone remodeling induced by bisphosphonates or inhibition of osteoclast function, which interferes with healing of the microfractures and trauma occurring after dental extraction, have been hypothesized as potential mechanisms for ONJ, but thes

• Remote monitoring offers ongoing opportunities for managemen

  2019-06-28

  

  Remote monitoring offers ongoing opportunities for management from three perspectives: Concept of remote monitoring for Adarotene failure Most HF-related hospitalizations are due to fluid accumulation, and careful surveillance of a patient\'s fluid status and symptoms is important [20]. To effec

• br Conclusions Implantable monitoring devices have become hi

  2019-06-28

  

  Conclusions Implantable monitoring devices have become highly useful diagnostic tools for AT/AF [32]. However, the accuracy of the obtained diagnostic information is influenced by several factors, including the presence of non-AT/AF events, such as RNRVAS or PMT, caused by VA conduction or by sub

• Introduction Paraneoplastic immune mediated encephalopathy i

  2019-06-28

  

  Introduction Paraneoplastic immune-mediated encephalopathy is a newly described disease. In 2005, Vitaliani et al first reported that four young women with ovarian teratoma (OT) had developed acute psychiatric and neurologic symptoms, e.g., seizures, memory deficits, decreased level of consciousnes

• However the patient was later

  2019-06-28

  

  However, the patient was later re-admitted with frequent palpitation symptoms similar to those exhibited prior to the initial RFCA. Despite oral class I antiarrhythmic drug and beta-blocker treatment, ECG revealed incessant ATs and symptomatic AF (Fig. 2), so repeat RFCA was performed. Intravenous b

• El t tulo del poema define

  2019-06-28

  

  El título del poema define una intertextualidad que se refuerza tipográficamente por medio de las cursivas del primer verso. La diferencia gráfica entre las palabras que integran este verso resalta el signo de la negación —el adverbio “no”— expresando una contradicción que culmina en los dos versos

• The primary tool in the pharmacological management of PTSD i

  2019-06-27

  

  The primary tool in the pharmacological management of PTSD is the use of selective serotonin reuptake inhibitors [55,56], but positive response rates are generally limited. In addition, non-pharmacological treatment such as CBT has been shown to be effective for PTSD [57]. Psychological distress

• Others have observed the marked differences in clinicopathol

  2019-06-27

  

  Others have observed the marked differences in clinicopathological characteristics between breast cancer subtypes by IHC study. However, they reported that triple negative and HER2 patients are at high risk of recurrences after adjusting for age, stage and histological grade. Our data support this o

• br Discussion Unfortunately it was not possible to perfom a

  2019-06-27

  

  Discussion Unfortunately it was not possible to perfom a RCT comparing medical ozone gas therapy in respect to standard therapy because all our 24 patients had been previously treated with various cycles of antibiotic therapies before we could start the therapy with O3 gas. Moreover the patients

• br Conventional mapping and ablation of ventricular tachycar

  2019-06-27

  

  Conventional mapping and ablation of ventricular tachycardia Substrate mapping during sinus rhythm Technical issues Conclusion Conflict of interest Introduction By eliminating the arrhythmogenic focus, catheter ablation can be a curative therapy of ventricular tachyarrhythmias (VTA

• Hereditary syndromes with increased risk for gastric cancer

  2019-06-27

  

  Hereditary syndromes with increased risk for gastric cancer include: 1) hereditary diffuse gastric cancer, 2) Lynch syndrome/hereditary non-polyposis colorectal cancer, 3) juvenile polyposis syndrome, 4) Peutz-Jeghers syndrome and 5) familial adenomatous polyposis. Hereditary diffuse gastric cancer

• Cryotherapy related soft tissue injury

  2019-06-27

  

  Cryotherapy related soft tissue injury usually occurs within a few weeks postoperatively. Skin necrosis is a significant complication if freezing of the superficial surface occurs. Constant irrigation of the adjacent tissues with warm saline reduces the chance of skin necrosis. Our rate of infection

• A recent meta analysis has shown that an enlarged

  2019-06-27

  

  A recent meta-analysis has shown that an enlarged LA increases the risk of AF recurrence after a single CPVI, regardless of the follow-up duration [5]. This finding can be applied to paroxysmal and persistent AF [6,7]. In clinical practice, measurement of LAD can provide a window into the status of

• br Discussion Digoxin has multiple effects on the

  2019-06-27

  

  Discussion Digoxin has multiple effects on the myocardium and has multiple cardiac-related uses. In the treatment of atrial fibrillation, digoxin increases vagal tone to prolong the refractory BX-912 at the AV node, decreasing ventricular response to higher atrial rates [3]. Toxic doses of digox

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