• In addition to CAF in

  2019-05-17

  

  In addition to CAF in the primary tumour microenvironment, it is tempting to speculate that fibroblasts within the bone itself may play a role in the establishment of metastatic deposits. Fibroblasts form a major component of the bone marrow stroma and regulate haematopoiesis by secreting a range of

• In humans the two primary bile acids

  2019-05-17

  

  In humans, the two primary bile acids CA and CDCA make up approximately 70%–80% of the total bile 4-ethylphenyl sulfate pool. DCA is the major secondary bile acid, which may account for approximately 20% of the total bile acid pool. Among all bile acid species, the secondary bile acid LCA is highly

• The patient was consented to treatment on clinical

  2019-05-16

  

  The patient was consented to treatment on clinical trial NCT02527447 and received treatment with salvage chemotherapy of mitoxantrone 12mg/m2/day IV on days 1–3, etoposide 200mg/m2/day continuous IV infusion (CIV) on days 8–10, and cytarabine 500mg/m2/day CIV on days 1–3 and 8–10 (EMA). Infectious p

• br Introduction Percutaneous transcatheter device closure of

  2019-05-16

  

  Introduction Percutaneous transcatheter device closure of atrial septal defects (ASD) has become an effective alternative therapy to surgical repair in patients with secundum type ASD. Amplatzer ASD or ventricular septal defect (VSD) occluders were used for the closure of ASDs or VSDs, respective

• br Case report The patient then achieved

  2019-05-16

  

  Case report The patient then achieved disease-free status as noted in a series of routine image studies during regular follow-up at our oncology clinic. In November 2011, she presented due to hematuria for several days. Diagnostic cystoscopy showed a mass lesion on the urinary bladder. Whole body

• Certainly dynamic interactions between DTCs and stromal cell

  2019-05-16

  

  Certainly, dynamic interactions between DTCs and stromal adenosine deaminase inhibitor within the bone microenvironment disrupt bone homeostasis, which is normally tightly controlled, to fuel metastatic progression [18] (Table 1). For example, it is well established that osteolytic breast cancer DT

• The overall MSTS score in our study was

  2019-05-16

  

  The overall MSTS score in our study was 97.3%. The MSTS score after curettage treatment was 99%, better than that in previous studies, which ranged from 90% to 93%. Two cohort studies showed higher MSTS scores for patients who underwent intralesional curettage than those who underwent wide resection

• br Introduction Percutaneous transcatheter device closure of

  2019-05-16

  

  Introduction Percutaneous transcatheter device closure of atrial septal defects (ASD) has become an effective alternative therapy to surgical repair in patients with secundum type ASD. Amplatzer ASD or ventricular septal defect (VSD) occluders were used for the closure of ASDs or VSDs, respectiv

• When compared with lidocaine both amiodarone and nifekalant

  2019-05-15

  

  When compared with lidocaine, both amiodarone and nifekalant were proved similarly effective for ventricular arrhythmias suppression. These drugs, however, have characteristic adverse effects, such as negative inotropic and chronotropic outcomes (amiodarone), and QT prolongation resulting in torsade

• Efforts to estimate the global burden of

  2019-05-15

  

  Efforts to estimate the global burden of typhoid fever can be traced to a meeting of the Pan American Health Organization in 1984 and publication of the outcome in 1986. Although an important first step, the 1984 study was recognised as having a number of limitations including provision of scanty me

• De hecho la desordenada colecci n

  2019-05-15

  

  De hecho, la desordenada colección de los datos etnográficos se encuentra varias veces en conflicto con la propuesta de un proyecto sistemático que el fraile busca plantear, sin éxito, en el exordio de su obra. En las primeras páginas de la Relación, Pané esboza los confines de un modelo hermenéutic

• Una participaci n de particular relevancia fue

  2019-05-15

  

  Una participación de particular relevancia fue la de Hugo Chávez en el Fsm 2006, pues su discurso puede considerarse una síntesis de la comprensión desde la política institucional latinoamericana de izquierdas sobre los movimientos sociales. En su discurso, Chávez convocó chemical i was reading this

• Sin embargo la mayor a de los aventureros

  2019-05-15

  

  Sin embargo, la mayoría de los aventureros se quedó en la ensoñación, pues no logró hacerse de caudales, ni alcanzó encomiendas; de hecho, hacia 1540 y aun años después, el número de encomenderos en el gran Perú (hoy Perú, Bolivia y Ecuador) jamás rebasó los 500, indudablemente una minoría de la pob

• Di logo de amigos escritura y ficci n

  2019-05-15

  

  Diálogo de amigos, escritura y ficción se cruzan desde las primeras páginas: “Por dispares que fuéramos como escritores, la amistad cabía, porque sentíamos una compartida pasión por los libros. Tardes y noches conversamos de Johnson, de De Quincey, de Stevenson, de literatura fantástica, de argument

• For most health care professionals infectious disease

  2019-05-15

  

  For most health-care professionals, infectious-disease modelling is something of a black box. One can see the input assumptions (ie, what goes in) and the outputs (ie, what comes out), but what happens in between seems close to magic. Given their complexity, to understand any one of the models used

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