• On the basis of our

  2018-11-05

  

  On the basis of our genetic findings that hexokinase 2 (HK2)-mediated aerobic glycolysis, known as the Warburg effect, drives prostate tumor growth in xenograft model bearing /p53-deficient murine or human prostate cancer notch inhibitor (Wang et al., 2014), we designed preclinical studies to deter

• corticotropin releasing factor Multiple levels of evidence p

  2018-11-05

  

  Multiple levels of evidence presented here also suggest that in addition to the O-glycan pathway, three other major glycosylation pathways important in PCa are under the control of androgens. Firstly, one of these pathways is the HBP, which creates the amino-sugar conjugate O-GlcNAc which is known t

• br HIV Infection and the

  2018-11-05

  

  HIV Infection and the IL-33/ST2 response: Sounding the Alarm Given that IL-33 is rapidly released from damaged buy bupropion hydrochloride following tissue damage, necrosis and activation of the inflammasome (Martin and Martin, 2016), it has been suggested that IL-33 may play a role in the patho

• compellingly demonstrated that NSG mice develop

  2018-11-05

  

  compellingly demonstrated that NSG mice develop a human immune system and leukemia, and further show that RLI mediated anti-leukemia activity in the presence of lymphopenia conditions presenting the translational research community with a tractable model system to study leukocyte infusions for immun

• The androgen receptor AR is a ligand dependent transcription

  2018-11-05

  

  The androgen receptor (AR) is a ligand-dependent transcriptional factor that belongs to the nuclear receptor superfamily. Androgen/AR signals play important roles in normal liver function and in the development of liver diseases including HCC (Ma et al., 2014). Previous studies revealed a male predo

• Harman and Stewardson mentioned that only a few published

  2018-11-05

  

  Harman and Stewardson (2005) mentioned that only a few published studies explicitly described the link between environmental flow targets and dam operating rules. To resolve the river management-driven issues and bridge the gap between a simple minimum stream flow target and the great complexity of

• br Geological setting Ultramafic mafic nappes

  2018-11-05

  

  Geological setting Ultramafic-mafic nappes, as well as mélange consisting of marble and greenschist facies rocks are exposed along the Nujiang River in the studying area (Figs. 1 and 2). The NW-SE course of the Nujiang River is regarded as an important tectonic boundary, the trace of the Bongong-

• br IFL is associated with clinical symptoms

  2018-11-05

  

  IFL is associated with clinical symptoms The bulk of research identifying comorbidities with SDB has focused on purchase Calcium Ionophore I and hypoxia. However, there is evidence that IFL and sleep fragmentation also may lead to problems. Patients with UARS, defined by the presence of IFL asso

• br Conflict of interest br Acknowledgments The

  2018-11-05

  

  Conflict of interest Acknowledgments The project was supported partially by Keyghobad Ventures LLC under Grant No. 0731102, and our research work was conducted at the Gorge J. Kostas Nanoscale Technology and Manufacturing Research Center at Northeastern University. Introduction Over the pa

• br Mechanical model of the coupled system

  2018-11-05

  

  Mechanical model of the coupled system In this section we present the mechanical model of a deformable body coupled with a viscoelastic substrate through a distributed system of deformable elements. The deformable body along with the distributed system of coupling elements is inspired by a class

• br Results Response rate of participating pharmacists was

  2018-11-05

  

  Results Response rate of participating pharmacists was 70.6%, i.e., 60 out of 85 approached agreed to participate in the study. Number of packs sold in a month per pharmacy varied from 2 to 500 packs/month, with a mean of 62 packs every month. Thirty‐eight pharmacists claimed that clients took th

• Introduction Microelectrode arrays MEAs are substrate

  2018-11-05

  

  Introduction Microelectrode arrays (MEAs) are substrate-integrated extracellular electrode matrices kept in contact with cysteine protease in culture. MEA-based cell electronic interfaces enable the study of neuronal network processes, the evaluation of the effects of drugs and the electrophysiolo

• br Quantitative dataset at the three main stages of shell

  2018-11-03

  

  Quantitative dataset at the three main stages of shell calcification In a second approach, GeLC–MS/MS analyses combined to label free quantitative analysis based on spectral counting quantitative method were used to compare the respective abundance of distinct proteins at the initiation (I), rapi

• br Acknowledgments This data set was generated with

  2018-11-03

  

  Acknowledgments This data-set was generated with the financial support of the Partnerships for Enhanced Engagement in Science (PEER) initiative from the United States Agency for International Development [Grant no. PGA-2000003446] to TP. Data, experimental design, materials and methods The da

• For the samples sintered from the nanometric micrometric

  2018-11-03

  

  For the samples sintered from the 40% nanometric – 60% micrometric powders, with both compaction procedures, the elastic limit is within the 500–530MPa range. The direct-SPS sample presents a sharper strain hardening, especially in the beginning of the plastic deformation, for a maximum stress of 73

16376 records 1077/1092 page Previous Next First page 上5页 10761077107810791080 下5页 Last page