• In summary we developed a

  2018-10-22

  

  In summary, we developed a powerful strategy generating hemangiogenic FLK-1+ progenitors from ESCs. The unlimited access to hemangioblasts, the ultimate hematopoietic and vascular progenitors, warrants further investigations on potential clinical applications requiring hematopoietic, vascular repair

• In addition to regulating the pluripotent state SOX

  2018-10-22

  

  In addition to regulating the pluripotent state, SOX2 controls the formation of several cell types during fetal development, such as the nervous system (Ellis et al., 2004), anterior foregut endoderm (Que et al., 2007), and sensory cells of the taste bud and inner ear (Dabdoub et al., 2008; Kiernan

• The presence of condensin II

  2018-10-22

  

  The presence of condensin II at enhancer/promoter sites occupied by the Mediator coactivator and NIPBL suggests that it is recruited to these sites during transcription activation. To test this model, we used a well-characterized cell system with a stably transfected doxycycline (Dox)-inducible tran

• PSCs exhibit an unusual mode of

  2018-10-22

  

  PSCs exhibit an unusual mode of cell-cycle regulation with a truncated G1 and a large percentage of S phase cells (Singh and Dalton, 2009). As PSCs differentiate, the ion channel is remodeled, such that G1 is lengthened and the relative amount of time associated with S phase cells is reduced. Recen

• Our previous study showed that miR was highly expressed in

  2018-10-22

  

  Our previous study showed that miR-210 was highly expressed in neural precursor KB-R7943 mesylate (NPCs) under hypoxic conditions (Liu et al., 2011). To further understand the role of miR-210 in NPCs, TargetScan was used to search for miR-210 putative target genes. Based on conserved seed sequences

• DNA fragmentation is an essential

  2018-10-20

  

  DNA fragmentation is an essential component of PCD. Of several nucleases that were tested for their involvement in charontosis, EndoG emerged as a likely candidate, although a role for CAD cannot be discounted due to the degradation of ICAD observed 44 h after ETO treatment. EndoG is activated in st

• Studies using freshly isolated cells

  2018-10-20

  

  Studies using freshly isolated thapsigargin from the stromal vascular fraction (SVF) of sWAT characterized ASCs by their plastic adherence in culture, colony-forming capacity and the expression pattern of distinct cell surface markers (Mitchell et al., 2006). These cells can promote angiogenesis (R

• Aside from phenotypic differences functional

  2018-10-20

  

  Aside from phenotypic differences, functional differences have also been described between adult BM and FL LT-HSCs (Higuchi et al. 2003; Bowie et al. 2007). For instance, FL LT-HSCs display significantly faster expansion kinetics when grafted in adult mice, compared with LT-HSCs from BM of 8-week-ol

• br Materials and methods br

  2018-10-20

  

  Materials and methods Results Discussion Cell-based siRNA microarrays have made it possible to analyze phenotypic changes in cells, including increases or decreases in cellular products and variations in cell morphology. Such methods also provide advantages over conventional methods, such a

• br Materials and methods br Resource table br

  2018-10-20

  

  Materials and methods Resource table Resource details Urine epithelial cells underwent the reprogramming procedure using the CytoTune®-iPS 2.0 Sendai Reprogramming Kit (Thermo Fisher Scientific, USA) containing reprogramming vectors with the four Yamanaka factors, Oct3/4, Sox2, Klf4 and c-M

• Dental pulp stem cells DPSCs also known as dental

  2018-10-20

  

  Dental pulp stem amantadine hcl (DPSCs), also known as dental pulp-derived mesenchymal stem cells, are a multipotent adult stem cell population that has a high proliferative potential. DPSCs in this study isolated from adult teeth are easily accessible and cryopreservable for long periods (Papaccio

• On the other hand cell lines VUB and

  2018-10-20

  

  On the other hand, cell lines VUB01 and VUB14 showing the highest methylation grade, expressed more HLA-G mRNA compared to the low methylated cell lines VUB19_DM1 and VUB31_FSHD suggesting that next to promoter CpG methylation other mechanisms were involved in HLA-G expression control. Cis-regulator

• In conclusion the Olfm IRES eGFPCreERT allele described here

  2018-10-20

  

  In conclusion, the Olfm4-IRES-eGFPCreERT2 allele described here provides a tool, separate from Lgr5, that can be used to further characterize intestinal stem cells. Experimental Procedures Acknowledgments We thank Hugo Snippert for analysis of the Olfm4 animals and Valentina Sasselli for a cr

• The meniscus is best described as

  2018-10-20

  

  The meniscus is best described as a fibrocartilage (Benjamin and Evans, 1990) comprising an outer, “red vascularized” part and an inner “white, unvascularized” part harboring round fibrochondrocytes (Hellio Le Graverand et al., 2001). Additionally, the outer surface of the meniscus is enclosed by a

• br Results br Discussion hESCs demonstrate the potential to

  2018-10-20

  

  Results Discussion hESCs demonstrate the potential to serve as a starting cell population for bone regeneration, and previous studies report effective differentiation of hESCs to osteogenic lineage (Arpornmaeklong et al., 2010; Kärner et al., 2009). However, it remains important to better defi

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